Dry the salmon filets very well with paper towels. Toss together the smoked paprika, chili powder, lime zest, garlic and onion powders, and a good pinch of salt and pepper. Rub the seasonings over the salmon filets. Drizzle with 1 tablespoon olive oil.
Heat 2 tablespoons olive oil in a skillet over medium heat. Place the salmon skin-side down and sear 3-4 minutes, then flip and cook 3 minutes longer or until desired doneness. Move to a plate.
In the same skillet, stir the onion until fragrant, about 2-3 minutes. Add the garlic and oregano and stir an additional minute. Pour in the coconut milk and toss in the cream cheese. Season with salt and pepper. Bring to a simmer and stir until the cream cheese dissolves, about 5-8 minutes. Remove the pan from the heat and stir in the cilantro and lime juice.
Add the salmon back into the skillet and baste with the sauce. Divide onto plates and serve with steamed rice, tortilla chips, and extra limes, as desired.
Keyword cilantro, coconut, lime, main course, one skillet, pescatarian, salmon, weeknight dinner