Pat the salmon filets very dry and place onto a cutting board or plate.
On a shallow plate, toss together the flour, smoked paprika, garlic and onion powders, oregano, and a heavy pinch each of salt and pepper.
Melt 2 tablespoons of the butter in a large skillet over medium heat. Dredge both sides of each salmon filet in the flour mixture, gently shaking off excess. Immediately add to the pan. Cook 4-5 minutes per side until golden and crispy. Move to a plate and set aside.
Melt the remaining 2 tablespoons of butter in the same skillet, then toss in the oregano and garlic and saute until fragrant, about 30-60 seconds.
Pour in the white wine and simmer until reduced by half, about 2-3 minutes, then stir in the honey, balsamic, broth, and blueberries. Simmer 5 minutes, or until the blueberries begin to burst and the sauce turns a vivid violet color. Stir in the lemon juice and add a shake each of salt and pepper, to taste.
Nestle the salmon filets back into the sauce and heat until warmed through. Spoon the sauce over the salmon as it bathes.
Serve with fresh basil or oregano, over mashed potatoes, steamed rice, or polenta.