Preheat oven to 350 degrees. Line two large baking sheets with parchment.
Melt the butter in a heat-safe bowl in the microwave for 1 minute. Whisk in the Worcestershire sauce, dijon, garlic and onion powders, parmesan, and a generous pinch of salt and pepper.
Dump the saltines and pretzels into a very large bowl. I use my Dutch oven for this. Pour in the butter mix and toss for 2-3 minutes with your clean hands or a wooden spoon until everything is fully coated.
Spread the crackers and pretzels in a single onto the prepared baking sheets. Bake 15-20 minutes until golden and toasty. WATCH CLOSELY. This shit will burn up if you stop paying attention to it. Cool the crackers on the pan before serving with your favorite dips and spreads.